To assess the role of SETD2 in SMAD4‐mutant CRC, the intestinal epithelium‐specific SETD2 and SMAD4 deficiency mouse strain (Setd2F/F;Smad4F/F; Villin‐Cre mice, here we referred as Smad4Vil‐KO;Setd2Vil‐KO mice) were generated by Villin‐Cre mice with Smad4‐flox29;Setd2‐flox mice (Smad4F/F;Setd2F/F mice). The gene discussed is SMAD4; the disease is colorectal carcinoma.