As the degree of insulin resistance increased, the proportion of patients with diabetic nephropathy and history of fatty liver, level of SBP, DBP, BMI, FBG, weight, WHR, UA, TG, TC, AST, ALT, GGT, WBC, PHR, TG/HDL‐C, TC/HDL‐C, and LDL‐C/HDL‐C in early‐onset T2DM showed an upward trend (p < .05). Here, GPT is linked to diabetic kidney disease.