SOST and obesity due to melanocortin 4 receptor deficiency: Although we previously reported that SOST is especially produced by senescent endothelial cells in vitro (Schafer et al., 2020), this negative regulator of bone formation is a protein released predominantly by osteocytes (Delgado‐Calle et al., 2017) and previously reported to increase with weight loss in older adults with obesity when diet was not combined with exercise (Armamento‐Villareal et al., 2012).