Notably, several basal progenitor state factors (Hoxc13, Pax9, Gli2, Krt15) displayed paradoxical downregulation (Extended Data Fig. 4b), indicating that EY-driven transcriptional changes do not reflect a physiologic OEPC cell state, but rather constitute a unique cellular state related to tumor initiation. The gene discussed is HOXC13; the disease is neoplasm.