Our analysis predicts the repression of TCF7/LEF1 expression by stem-related TFs (ie, MEF2C, IRF1, and LYL1) in ETP-ALL, and activation of TCF7/LEF1 by core TFs of T-cell commitment (ie, BCL11B, SIX6, and TCF7L2) in Near-ETP T-ALL (Extended Data Fig. 2d-e) and Non-ETP T-ALL (Supplementary Data Fig 4c). This evidence concerns the gene TCF7L2 and acute lymphoblastic leukemia.