To ask whether TCF7 and LEF1 have an analogous, T-lineage specific function in T-ALL blasts, we computationally inferred the regulators and targets of TCF7 and LEF1 in ETP, Near-ETP and Non-ETP T-ALL by constructing subtype-specific transcriptional regulatory networks. The gene discussed is TCF7; the disease is acute lymphoblastic leukemia.