While BMP-like leukemias harbored fusion products known to drive high HOXA cluster expression, including MLLT10, KMT2A, NUP214, and direct HOXA::TCR fusions, T-specified leukemias had fusions to ZFP36L2 (involved in cell cycle control during T-cell beta selection) and TLX1/3. Here, MLLT10 is linked to leukemia.