Notably, ETP and Near-ETP patients with higher expression of the TCF7/LEF1 signature had more favorable outcomes within AALL0434 (Extended Data Fig 2g-i), with TCF7/LEF1 signature having prognostic significance independent of MRD and CNS status in ETP-ALL patients (92.7% vs 79.3% 5-year OS, p = 0.024, Extended Data Fig. 2h). This evidence concerns the gene TCF7 and acute lymphoblastic leukemia.