Further, a marked increase in uncoupling protein 3 (Ucp3) and Krüppel-like factor 15 (Klf15) expression in the skeletal muscle (Fig. 9C) may promote lipid utilization and help mitigate lipid-induced insulin resistance in Ctrp10 KO female mice (84, 85). Here, C1QL2 is linked to Insulin resistance.