MAPT and tauopathy: The impact of tau pathology and Dap12 deletion on TEMM2 or NRG3 was further confirmed by Western blot analysis, illustrating increased levels of TEMM2 and NRG3 proteins in the cortical tissue of tauopathy-afflicted brains, which is mitigated in DAP12 loss (Fig. 6F–H and supplementary table 6).