Paradoxically, inactivation of DAP12 normalizes aberrant microglial signaling associated with AD pathologies, ameliorates abnormal electrophysiological activity and improves learning deficits in both amyloid and tauopathy mouse models13,14,15, indicating that removal of DAP12 confers brain resilience in response to the toxicities of AD pathologies. Here, TYROBP is linked to Alzheimer disease.