Using MC1 antibody, which recognizes conformation-specific tau relevant to AD, and AT8 antibody for phosphorylated tau at Ser202 and Thr205 epitopes, we observed a significant increase in MC1 staining within the hippocampal region upon Dap12 deletion (Fig. 1C, D and supplementary table 1). This evidence concerns the gene MAPT and Alzheimer disease.