P2RY12 and tauopathy: To investigate the impact of Dap12 deletion on microglial response to tauopathy, we subclustered microglia expressing microglial hallmark genes Csf1r, P2ry12, and Siglech (Supplementary Figure 3B) into four distinct subpopulations based on subcluster marker genes (Fig. 3A, supplementary Fig. 4A and supplementary table 3).