MAPT and Alzheimer disease: To establish the relevance of the mouse model tau pathology-inducible intermediate oligodendrocyte (iOli)-like state in relation to human AD, we conducted a re-analysis of oligodendrocyte clusters within our previously published single-nucleus RNA sequencing (snRNAseq) dataset encompassing both AD and non-AD control samples (n=8), with matched age, tau burden and clinical dementia ratings43.