SPP1 and tauopathy: In contrast, MG2 and MG4, disease-associated cells induced by tauopathy (Fig. 3A, B), exhibit higher levels of proinflammatory genes like Apoe, Spp1, Nfkb1, and Akt3, as well as STAT3, IL-8, NF-kB, and JAK/STAT signaling (Fig. 3C–F and supplementary table 3).