In this study, we explored the efficiency of ultra-high dose fractionated radiation therapy for human GBM in immunocompetent mice using the described immunological tolerance induction protocol.11 We also investigated radiation-induced brain injury in both wild-type mice and HIF-1α+/− heterozygote mice to better understand the role of HIF-1α signaling in radiation-induced vascular damage. The gene discussed is HIF1A; the disease is glioblastoma.