PPARD and cystic fibrosis: Since eDNA is a structural component of Pseudomonas aeruginosa biofilms (Allesen-Holm et al., 2006), it is possible that Nuc1 may passively contribute to P. aeruginosa biofilm formation and dispersal during S. aureus/P. aeruginosa coinfection in the airways of cystic fibrosis patients (Wieneke et al., 2021).