TP63 and cancer: Remarkably, our analysis of the Cancer Dependency Map CRISPR screening data from >1,000 cancer cell lines33 revealed that MED12 was in the top 1% of genetic co-dependencies of TP63 among ~18,600 genes that were evaluated (Fig. 4d), a correlation that did not exist for other core Mediator subunits (Supplementary Table 1).