However, there are several examples of AEU that could affect CHD function: (1) many unique exons in Plectin adjacent to the N‐terminal CHD change actin affinity and binding partners (Wiche, 2021) (2) alternative 1st exons in filaminA near the N‐terminus CHD1/2 domains, mutations in which cause complex human disease with smooth muscle‐dependent chronic intestinal pseudo‐obstruction as one feature (Chung et al., 2021; Jenkins et al., 2018; Zada et al., 2023). This evidence concerns the gene PLEC and chronic intestinal pseudoobstruction.