Tumor necrosis factor-α in the kidney is mainly produced by macrophages.[34] However, how macrophages of different phenotypes participate in the progression of DKD has not been fully defined.[35] Traditionally, it is believed that macrophage M1 is involved in the initial stage of inflammation and is associated with tissue damage and pro-inflammatory function, whereas the M2 phenotype mediates repair and wound healing, mainly playing an anti-inflammatory and pro-angiogenic role. The gene discussed is TNF; the disease is diabetic kidney disease.