ALB and diabetic kidney disease: The immune response is involved in the pathogenesis and progress of DKD.[4] In renal biopsy specimens of DKD patients at various stages, the infiltration of immune cells and increased expression of inflammatory mediators have been observed, among which macrophages are the most important immune cells.[5] The accumulation of macrophages in the kidney is closely related to urinary albumin excretion, estimated glomerular filtration rate (eGFR), and interstitial fibrosis score.