Probiotics reportedly prevented the IgE-associated allergy including eczema.[22,23]B longum BB536 improved nasal blockage and rhinorrhea scores without inhibiting the elevation of JCP-specific IgE.[8] In the current study, NTM048 also improved nasal blockage in Japanese cedar pollinosis without inhibition of elevation of JCP-specific IgE (Table 3). This evidence concerns the gene IGHE and allergic disease.