Cancer cells escape immune surveillance by altering their surface antigens to evade detection and destruction by lymphocytes.[41] Besides, they can escape immune recognition by modulating the immune checkpoint expression.[42] The abnormal expression of immune checkpoint expression inhibits the ability of cytotoxic T-cells to eliminate cancer cells.[43] Therefore, ANO6 elevation might affect tumor immune microenvironment and accelerate tumor immune escape. This evidence concerns the gene ANO6 and neoplasm.