This suggested that ANO6 overexpression might promote the polarization of macrophages, which has an intimate correlation with the immunosuppressive state of the tumor.[23] Besides, ANO6 had an obvious negative association with CTLA4 (r = −0.15, P < .05) and PD-1 (r = −0.24, P < .05), but was slightly positively correlated to PD-L1 (R = 0.09, P < .05) (Fig. 7C). Here, CD274 is linked to neoplasm.