Instead, in late-stage, it exerts pro-tumor effects by regulating genomic instability, EMT, neovascularization, cell motility, immune invasion, and metastasis.[30] ECM components provide cells with biochemical and biomechanical cues and represent a central role in BC cancer progression and metastasis.[31,32] Therefore, the authors speculated that ANO6 might affect BC progression and unfavorable clinical outcomes by regulating these key pathways. This evidence concerns the gene ANO6 and breast cancer.