Chen and colleagues showed that isoproterenol-induced ventricular hypertrophy activates VDR expression and hBNP promoter, suggesting a direct relationship between VDR and hBNP promotor.[55] Previous studies revealed that VDR is a more sensitive BA receptor than FXR and pregnane X receptor (PXR), particularly for LCA and its main metabolite 3-keto-LCA55. The gene discussed is VDR; the disease is cardiac hypertrophy.