NR1H4 and hydrops fetalis: They further confirmed their findings in an animal model of myocardial ischemia/reperfusion injury.[48] By triggering the AMPK signaling pathway, FXR ameliorates ET-1-mediated cardiomyocyte injury.[50] All of these findings indicate that the FXR receptor may play a role in the development and progression of HF by influencing lipid and glucose metabolism, oxidative stress, inflammation, cell death, and vascular remodeling.