A low CD4/CD8 ratio was considered predictive of poor prognosis with non-AIDS related events or death even during effective ART.[37,38] In our study, the CD4/CD8 ratio did not increase significantly among participants previously treated with ART, although the ratio slightly improved after 8 weeks of treatment, which might reflect lower immunological recovery for TE individuals than TN people living with HIV/AIDS. The gene discussed is CD4; the disease is AIDS.