Among these proteins, the class IIa HDAC subfamily, which includes HDAC4, HDAC5, HDAC7, and HDAC9, shares the specific characteristics with all other HDACs, such as interaction with transcription factors and tissue specificity.[5] Among them, HDAC7 seems to act as a lymphoid-specific transcription inhibitor of various HDACs.[19] Here, we found that HDAC7 can be used as a biomarker for better prognosis and longer survival in patients with DLBCL. This evidence concerns the gene HDAC4 and diffuse large B-cell lymphoma.