According to previous studies, loss of HDAC7 dramatically stunts early B cell development and causes severe lymphocytopenia in peripheral organs as well as confusion in the lineage of pro-B cells.[6] These findings shed light on the mechanisms by which HDAC7 loss or dysregulation may lead to B cell-based hematological malignancies.[7] However, the predictive value of HDAC7 in DLBCL in clinical practice has not yet been explored. Here, HDAC7 is linked to hematologic disorder.