IL6 and endothelial dysfunction: Several studies have linked the severity of ED, as well as its presence, to markers and mediators of subclinical inflammation and endothelial dysfunction.[15] Furthermore, research has revealed a negative association between 5-item International Index of Erectile Function scores and the levels of fibrinogen, IL-1β, vascular hemophilia factor, and IL-6.[16] While the precise mechanism by which inflammation causes ED remains unclear, there is an undeniable and robust connection between the 2.