Another study showed that patients who developed end-stage renal disease and started with HD presented deteriorated nutritional parameters, trends of decrease in weight, BMI and fat mass, as well as increase in pro-inflammatory cytokine markers such as CRP and IL-6.[27] Furthermore, the level of albumin was negatively correlated with pro-inflammatory status.[28] The protein content of the elderly was lower, and the nutritional status was poorer in the sarcopenia group, which also increased the readmission rate. This evidence concerns the gene CRP and stage 5 chronic kidney disease.