Another study showed that patients who developed end-stage renal disease and started with HD presented deteriorated nutritional parameters, trends of decrease in weight, BMI and fat mass, as well as increase in pro-inflammatory cytokine markers such as CRP and IL-6.[27] Furthermore, the level of albumin was negatively correlated with pro-inflammatory status.[28] The protein content of the elderly was lower, and the nutritional status was poorer in the sarcopenia group, which also increased the readmission rate. The gene discussed is IL6; the disease is chronic kidney disease.