TPO and hyperthyroidism: Another study found that age >45 years, heart rate >90 beats/minute, thyroid mass >35 g, course of hyperthyroidism >3 years, FT4 ≥70.5 pmol/L, thyroid peroxidase antibody >360 IU/mL, and TRAb >15 IU/L are all risk factors for increasing hyperthyroidism liver injury, further narrowing the scope of the high-risk group of hyperthyroidism liver injury.[13]