TBX21 and ulcerative colitis: It was reported that DA levels in the inflamed mucosa of UC patients were markedly lower than in controls.[45] Similarly, decreased levels of DA were detected in the colonic mucosa of TNBS-induced rats,[46] in the colonic mucosa of DSS- induced mice,[47] and in the feces of TRUC (T-bet−/− Rag2−/− ulcerative colitis) mice.[48] In UC, a decrease in DA levels may lead to a weakening of its inhibitory effect on PRL secretion, ultimately resulting in an increase in PRL levels.