IL-8 (1–3 ng/mL) is a non-structural protein secreted by neutrophils and macrophages, which plays an important role in the proliferation of angiogenesis and, in particular, its concentration dramatically increases in the presence of oropharyngeal squamous cell carcinoma (OSCC), which is one type of head and neck cancer [31,32,33,34]. This evidence concerns the gene CXCL8 and head and neck cancer.