The mean values of hs-CRP, fibrinogen, insulin, and homeostasis model assessment were significantly higher in individuals with grade-III obesity than grade-II obesity (0.76 ± 0.53 vs. 1.73 ± 1.75, p = 0.005), (338.44 ± 72.27 vs. 416.37 ± 104.48, p < 0.0001), (17.07 ± 8.03 vs. 23.28 ± 12.75, p = 0.015), and (3.89 ± 2.14 vs. 5.49 ± 2.93, p = 0.008), respectively. Here, INS is linked to obesity due to melanocortin 4 receptor deficiency.