Based on the above results, we further verified that CD8+ T cells were the target cells for 1,25(OH)2D3-induced immunosuppressive activity in vitiligo by applying 1,25(OH)2D3 at concentrations of 10 nM and 100 nM to CD8+ T cells isolated from vitiligo patients and healthy controls for 72 h. This evidence concerns the gene CD8A and vitiligo.