Therefore, we tested the relationship between the level of serum vitamin D and vitiligo in a cross-sectional study and found that, compared to patients with sufficient 1,25(OH)2D3, the 1,25(OH)2D3-deficient group had significantly higher VIDA scores and increased percentages of CD8+ T cells/T cells and IFN−γ+ CD8+ T cells/CD8+ T cells in the blood, indicating specific immune abnormalities. Here, CD8A is linked to vitiligo.