Although the specificity and mechanism of this receptor’s function must still be better clarified, it is plausible to suggest that knowledge of the CD36 variants of an individual—which preferentially favor the intake of some nutrients and adversely affect the consumption of others—may help to prevent chronic diseases and also improve the personalization of interventions against obesity and obesity-related complications. This evidence concerns the gene CD36 and obesity due to melanocortin 4 receptor deficiency.