NLRP3 and rheumatoid arthritis: In RA patients, the activation level of the NLRP3 inflammasome in macrophages within synovial tissue is significantly increased [94], and finally, the pyroptosis can impact the biological characteristics of fibroblast-like synoviocytes (FLS) [95], demonstrating the bridging role of the NLRP3 inflammasome in connecting immune cells and non-immune cells in RA.