In conclusion, this study showed that both viable L. plantarum Zhang-LL bacteria and heat-killed strains could alleviate the progression of CRC in AOM/DSS mice, and that its mechanism was to inhibit the arachidonic acid metabolism pathway by regulating the abundance of the dominant flora Lactobacillus in the gut microbiota and upregulating the expression of genes related to the BCR regulatory process mediated by CD22 to improve host immunogenicity. Here, BCR is linked to infectious otitis media.