LCK and cancer: Figure 1 provides a structural depiction of LCK, highlighting an N-terminal domain (SH4 domain), an SH3 domain, an SH2 domain, and a C-terminal tyrosine kinase structural domain. The activation of LCK is a pivotal phase in TCR signal transduction, playing a vital role in the pathogenesis of various inflammatory and autoimmune disorders such as rheumatoid arthritis, asthma, and cancer [9,10,11].