The AHR-CYP1A1 pathway was associated with cancer progression [15,16,17] through metabolizing some xenobiotics into mutagenic epoxide intermediates or interacting with other signaling pathways that are responsible for cell invasion, migration, etc. Therefore, elucidating the effects of alizarin on the AHR-mediated CYP1A1 pathway with human cell-based assays may help us to better understand its carcinogenic or anticancer properties. The gene discussed is AHR; the disease is cancer.