INS and diabetes mellitus: Thus, this research aims to evaluate the efficacy of sesamin (the most abundant compound in sesame seeds) in alleviating the symptoms of diabetes (i.e., body weight loss, high blood glucose level, and glycosylated hemoglobin, low insulin level, decrease in serum amylase activity accompanied by a decrease in high-density lipoprotein (HDL), elevated serum triglyceride (TG), increased cholesterol, lowered serum amylase, and hepatic injuries) using STZ-induced rat models.