For example, the pyrazole target I (Figure 1), bearing 5-oxo-5H-indeno-[1,2-b]pyridine-3-carbonitrile, exerts its promising cytotoxic activity against human breast MCF-7, lung A-549 and colorectal HCT-116 cancer cell lines through the inhibition of six enzymes (AKT1, AKT2, BRAF V600E, EGFR, p38α and PDGFRβ) at 100 μM [13]. Here, EGFR is linked to cancer.