OCLN and acute kidney injury: A range of inflammatory cytokines, such as tumor necrosis factor α (TNF-α) and interleukin 1β (IL-1β), are released in the bloodstream of patients with AKI, and these inflammatory factors are able to reduce the expression of Zonula occludens 1 (ZO-1) and Occludin in the gut, which can disrupt the intestinal barrier [5,7].