CRP and Cholecystitis, Acute: A previous study by Micic et al. [24] on 136 patients who underwent LC for acute cholecystitis found a similar cut-off value of 4.18 for predicting advanced AC with a 78.3% sensitivity and 74.3% specificity [24], while another recent study found a cut-off value of 4.17 for moderate to severe AC [35], with a predictive value similar to that of CRP.