For participants to be diagnosed with MS, they had to meet three of the five established criteria: fasting blood glucose > 100 mg/dL; or treatment with insulin or hypoglycaemic agents; treatment with antihypertensive drugs or blood pressure above 130/85 mmHg; HDL-C < 50 mg/dL in women and <40 mg/dL in men; triglycerides > 150 mg/dL; and abdominal circumference > 88 cm in women and >102 cm in men [19]. The gene discussed is INS; the disease is myeloid sarcoma.