ACE and sarcoidosis: In case sarcoidosis is regarded highly probable on the basis of collected clinical data, including supportive findings such as elevated serum ACE and/or sIL2R and others (Table 5), it is not uncommon, especially in centers with expertise in sarcoidosis, to decide on a “working diagnosis of sarcoidosis” and to refrain from further invasive diagnostic procedures for the patient, especially when patients are not threatened by organ failure or organ damage due to sarcoidosis and when indication to start immunosuppressive therapy is absent at that time, or the patient is frail.