ANGPT1 and aortic aneurysm: The protective role of Ang 1-7 in vascular remodeling was also explored in a model of aortic aneurysm (AA) [66,96,97]: Ma and coworkers reported that AVE0991 (a nonpeptide Ang 1-7 mimic) and Ang 1-7 attenuate the formation of abdominal AA induced by Ang II in ApoE-KO mice, reduce abdominal aorta remodeling, pro-inflammatory cytokines release and oxidative stress through the suppression of pP38 and pERK1/2 signaling pathway [66].