Exploring the role of ACE2 glycosylation on Ang 1-9, Ang 1-7, and MasR in cardiomyocytes from patients with type 2 diabetes (under poor or good glycemic control), it was found that hearts from diabetic patients presented higher levels of glycosylated ACE2 which is related with poor glycemic control and an increase in cardiac fibrosis and remodeling and lower levels of Ang 1-7, Ang 1-9 and MasR, therefore blunting the effect of RAAS inhibitors. Here, ANGPT1 is linked to type 2 diabetes mellitus.