Circulating levels of MMP-2, MMP-12, TIMP-1, TIMP-2, TIMP-3 and TIMP-4 were significantly associated with the presence of one, two and three cerebral MRI signs of SVD (p < 0.001, p = 0.041, p < 0.001, p < 0.001, p = 0.019 and p = 0.039, respectively) (Table 6). This evidence concerns the gene TIMP4 and snowflake vitreoretinal degeneration.