The use of biomarkers (such as procalcitonin (PCT) and C-reactive protein (CRP)), which bring information about inflammation, response to the infection, and response to the antibiotic therapy are associated with the clinical stability criteria (temperature ≤ 37.2 °C, heart rate ≤ 100 beats/min, respiratory rate ≤ 24 breaths/min, systolic blood pressure ≥ 90 mmHg, and oxygen saturation ≥90% or arterial oxygen tension ≥60 mmHg when the patient was not receiving supplemental oxygen), may improve the safe identification of patients that reach clinical stability. Here, CRP is linked to infection.