Studies show different risk factors associated with the requirement for glucose-lowering medications for glycemic control in pregnancies complicated by GDM such as age, pre-pregnancy BMI, prior history of GDM, glycated hemoglobin value at GDM diagnosis and family history of type 2 diabetes mellitus [19,20,21,22,23], as well as higher fasting and 2 h plasma glucose concentrations during OGTT [24,25] as strong indicators for insulin therapy. The gene discussed is INS; the disease is gestational diabetes.