Additionally, experimental evidence suggests that, aside from being a regulator of the cytoskeleton, ROCK also plays a significant role in the inflammatory process [80], with potential benefits of ROCK inhibition in treating conditions like rheumatoid arthritis [81] and Crohn’s disease [82], where it inhibits NF-kb activation and reduces the production of inflammatory cytokines. Here, NFKB1 is linked to rheumatoid arthritis.