Furthermore, a very recent study confirmed genetic prostate-specific AMPK activation to significantly attenuate both the development and the progression of prostate cancer, effects attributable to the induction of PGC1α and catabolic reprogramming of prostate cancer cells, which supports the theory that AMPK activation exerts a protective effect against cancer cell proliferation [41]. This evidence concerns the gene PPARGC1A and Familial prostate cancer.