In the study conducted by Yang et al., they demonstrated that the administration of anthracyclines or paclitaxel as chemotherapeutic treatments can stimulate exosome secretion by tumor cells, thereby abolishing chemosensitivity and promoting BCSCs’ expansion through the modulation of WNT/β-catenin and Notch signaling pathways and the activation of the transcription factor STAT3, leading to increased levels of miRNAs 378a-3p and 378d [114,128]. The gene discussed is STAT3; the disease is neoplasm.