CASP1 and diabetic cardiomyopathy: It has been reported that Sirt3 deficiency increased the expression of the inflammasome-related protein NLRP3, which promoted the recruitment of pro-inflammatory cells, caspase 1 activation, and pro-inflammatory cytokine secretion, ultimately exacerbating diabetic cardiomyopathy in these mice [41], and exacerbated diabetic cardiac dysfunction, mainly through Foxo3A-Parkin-mediated mitophagy [26].