Wang et al. (2016) found that baicalein prevents AAAs through the inhibition of ROS production in the aortic wall, a reduction in inflammatory cell accumulation in the aorta, downregulation of the angiotensin type 1 receptor (AT1R) and blocking mitogen-activated protein kinases (MAPKs) [29]. This evidence concerns the gene AGTR1 and achalasia-alacrima syndrome.