In particular, the Fourth Universal Definition of Myocardial Infarction [8] defines myocardial injury as a distinct condition characterized by at least one hs-cTnI or hs-cTnT value above the 99th percentile of the biomarker distribution values, assessed in a healthy adult reference population (99th upper reference limit—URL—value). This evidence concerns the gene TNNI3 and myocardial infarction.