TNNI3 and acute myocardial infarction: For ten years now, high-sensitivity immunoassays for cardiac troponin I (hs-cTnI) and cardiac troponin T (hs-cTnT) have been recommended by all the international guidelines as gold standard laboratory methods for the detection of myocardial injury and diagnosis of acute myocardial infarction (AMI) [8,14,15,16,19,24].