As the amount of daily renewal of myocardial tissue is too low to be detected by cardiac imaging techniques, such as magnetic resonance or positron emission tomography [46,47], the Fourth Universal Definition of Myocardial Infarction has defined myocardial injury considering the 99th percentile URL value of hs-cTnI and hs-cTnT assays as the cut-off value [8]. This evidence concerns the gene TNNT2 and myocardial infarction.