NRG1 and lung carcinoma: The same study treated EFM-19 reporter cells with media from H1299 lung cancer that expressed CD74-NRG1 and found that the fusion protein caused the phosphorylation of ERBB2 and ERBB3, which suggested the activation of HER2:HER3 autocrine receptor signaling; The phosphorylation of ERK and AKT was also observed [59].