The coefficient for each aDCRG is displayed in Figure 3D. Furthermore, there are significant discrepancies in the mRNA levels of most of these genes between tumor tissues and adjacent normal tissues based on the training set (Figure S3A) and the second validation set (TCGA-COAD, Figure S3B).(1)Risk score=0.902×Exp(CMKLR1)+0.897×Exp(C16orf78)+0.724×Exp(LRRC41)+0.606×Exp(YIPF4)+0.604×Exp(GAS6)+0.550×Exp(YIPF6)+0.503×Exp(PLEC)+0.498×Exp(PIWIL4)+0.364×Exp(INHBB)−0.195×Exp(IL17RB)−0.299×Exp(ASL)−0.318×Exp(LY75)−0.405×Exp(APOL3)−0.439×Exp(EPHB2)−0.512×Exp(APOL4)−0.636×Exp(SLC22A1)−1.481×Exp(RPS4X). This evidence concerns the gene PIWIL4 and neoplasm.