In transgenic AD mouse models, two different methods have been developed to reduce ROS production: (1) Tg2576 AD mouse model overexpressing a mitochondrial targeted catalase is a method that marks hydrogen peroxide production [121], and (2) Tg19959 mouse model overexpressing a manganese superoxide dismutase is a method targeting superoxide generation production [2]. This evidence concerns the gene SOD2 and Alzheimer disease.