Reddy’s laboratory crossed Drp1 +/− mice with AβPP transgenic mice (Tg2576 line) and created double mutant mice—Drp1 +/− xAβPP in which he revealed, by performing mitochondrial functional assays, that mitochondrial dysfunction is reduced compared to AβPP mice, suggesting that reduced Drp1 protects against Aβ toxicity, mitochondrial dysfunction, and synaptic damage in AD [176]. Here, APP is linked to Alzheimer disease.