MAPT and Alzheimer disease: Another particular aspect of the study by Bobba et al. [139] concerned the direct interaction of Aβ with complex I. At that time, a case of direct interaction had already been identified represented by the interaction of Aβ with a Tau fragment (the NH2-26-44 fragment), derived from neurotoxic NH2 of the human Tau40 isoform (441 amino acids), in human AD synapses, in association with the mitochondrial ANT-1 [247,251].