PLN and familial dilated cardiomyopathy: In the three patient cohorts, the MAF of the HRC p.(Ser96Ala) polymorphism was 40.9% among PLN p.(Arg14del) carriers (cohort 1), 43.9% for the overall ACM cohort (cohort 2), and 41.3% for the UK Biobank DCM cohort (cohort 3).