PLN and familial dilated cardiomyopathy: To follow up on this observation, the aim of our study was to examine (1) the presence of the HRC p.(Ser96Ala) polymorphism in the general population (control cohort); (2) the effect of the HRC p.(Ser96Ala) polymorphism on major cardiac events in three patient cohorts, namely carriers of the PLN p.(Arg14del) pathogenic variant (cohort 1); patients diagnosed with, or predisposed to, ACM (cohort 2); and DCM patients (United Kingdom (UK) Biobank, cohort 3).