Thymoquinone downregulated Bcl-xL, Bcl-2, and XIAP and upregulated and activated pro-apoptotic molecules like caspases-3 and -9, Bax, cytochrome c release, inhibitory tumor growth, Notch1, NICD, PTEN, and Akt/mTOR/S6 signaling [206,207,208,209]. The gene discussed is NOTCH1; the disease is neoplasm.